Design and synthesis of photoaffinity biotin labelled 2'-O-propargyl-guanosine / 药学学报
Acta Pharmaceutica Sinica
;
(12): 59-63, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-251817
ABSTRACT
Photoaffinity labeling is widely applied to demonstrate targets of small molecule ligands. In this paper, biotin photoaffinity labeled molecule with propargyl group 1 has been designed and synthesized, followed it's labeling of N2-acetyl-2'-O-propargyl guanosine 9 by "click chemistry". This technology presents delight development potential in labeling of second messenger cyclic nucleotide, antisense oligonucleotide or siRNA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biotin
/
Chemistry
/
Photoaffinity Labels
/
Click Chemistry
/
Guanosine
/
Ligands
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS