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Twelve benzene derivatives from Clausena excavata / 药学学报
Acta Pharmaceutica Sinica ; (12): 1689-1693, 2014.
Article in English | WPRIM | ID: wpr-251835
ABSTRACT
A new phenethanol, (2'R)-4-(2', 3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), along with other eleven known benzene derivatives (2-12) were isolated from the roots, stems and leaves of Clausena excavata (Rutaceae). Compounds 3 and 4 are new natural products, and compounds 5-8, 10-12 were isolated from C. excavata for the first time. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses including HSQC, COSY and HMBC experiments. 1 was tested for its cytotoxicities against A549, HeLa and BGC-823 cancer cell lines, and antimicrobial activities against Candida albicans and Staphylococcus aureus. The results showed that 1 did not exhibit cytotoxic and antimicrobial activities.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Staphylococcus aureus / Benzene Derivatives / Candida albicans / HeLa Cells / Magnetic Resonance Spectroscopy / Molecular Structure / Chemistry / Plant Stems / Plant Roots / Plant Leaves Limits: Humans Language: English Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Staphylococcus aureus / Benzene Derivatives / Candida albicans / HeLa Cells / Magnetic Resonance Spectroscopy / Molecular Structure / Chemistry / Plant Stems / Plant Roots / Plant Leaves Limits: Humans Language: English Journal: Acta Pharmaceutica Sinica Year: 2014 Type: Article