Twelve benzene derivatives from Clausena excavata / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1689-1693, 2014.
Article
in English
| WPRIM
| ID: wpr-251835
ABSTRACT
A new phenethanol, (2'R)-4-(2', 3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), along with other eleven known benzene derivatives (2-12) were isolated from the roots, stems and leaves of Clausena excavata (Rutaceae). Compounds 3 and 4 are new natural products, and compounds 5-8, 10-12 were isolated from C. excavata for the first time. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses including HSQC, COSY and HMBC experiments. 1 was tested for its cytotoxicities against A549, HeLa and BGC-823 cancer cell lines, and antimicrobial activities against Candida albicans and Staphylococcus aureus. The results showed that 1 did not exhibit cytotoxic and antimicrobial activities.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Staphylococcus aureus
/
Benzene Derivatives
/
Candida albicans
/
HeLa Cells
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Chemistry
/
Plant Stems
/
Plant Roots
/
Plant Leaves
Limits:
Humans
Language:
English
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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