A model-based meta-analysis to compare urate-lowering response rate of febuxostat and allopurinol in gout patient / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1674-1683, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-251837
ABSTRACT
This study aims to compare the urate-lowering response rate of febuxostat and allopurinol in gout patient using a model-based meta-analysis. The literature search identified 22 clinical trials of gout with a total of 43 unique treatment arms that met our inclusion criteria, and a total of 6 365 gout patients were included in the study. The response rates of allopuriol and febuxostat were characterized by Tmax model and Emax model respectively, and the effect of baseline serum uric acid (sUA) and patient type on the drug effect was tested. The results showed that allopurinol can reach an average maximum response rate of 50.8% while febuxostat can reach a 100% response rate within a very short time, and the ED50 was 34.3 mg. Covariate analysis revealed that baseline sUA has a negative effect on response rate of allopurinol, and a positive effect on the predicted ED50 of febuxostat. For patients who had shown inadequate response to prior allopurinol treatment, the average response rate was about half that of the allopurinol responder patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thiazoles
/
Uric Acid
/
Blood
/
Allopurinol
/
Gout Suppressants
/
Therapeutic Uses
/
Drug Therapy
/
Febuxostat
/
Gout
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article
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