Clinical significance of sequential monitoring minimal residual disease in childhood B-cell acute lymphoblastic leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 400-403, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-251941
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical significance of sequentially monitoring minimal residual disease (MRD) in childhood B-cell acute lymphoblastic leukemia (B-ALL).</p><p><b>METHOD</b>Eighty one B-ALL cases were enrolled in the study from January 2004 to December 2009. Leukemia cell markers were detected by flow cytometry at diagnosis, then regularly followed-up.</p><p><b>RESULTS</b>Of 81 cases, 80 achieved complete remission (CR) after induction therapy, 5-year event-free survival (EFS) was (76.80 ± 5.70)%. Among them, the EFS was (89.40 ± 5.90)% in standard risk group and (66.99 ± 13.60)% in intermediate risk group. Eight cases were screened for leukemia markers for MRD monitoring and identified in 68; and 5-year EFS was (79.10 ± 6.20)% and (62.50 ± 15.10)% (P > 0.05, respectively). MRD detection at day 35 in induction therapy showed that 52 of 68 cases were MRD negative (leukemia cells < 0.01%), the 5-year EFS being (88.50 ± 4.90)%, and 16 were MRD positive (leukemia cells ≥ 0.01%), the 5-year EFS being (42.10 ± 20.10)% (P > 0.05). Univariate analysis confirmed that there was a correlation between MRD monitoring and risk stratification. MRD detection at day 55 showed that among the 52 day 35 MRD negative cases, 51 were still negative, 1 positive, among 16 day 35 MRD positive cases, 14 (87.50%) turned negative, 2 still positive. Of the 68 cases, 9 were MRD positive within one year after CR (3 relapsed), 4 MRD positive after one year (2 relapsed) and 55 MRD negative (4 relapsed) (P > 0.05).</p><p><b>CONCLUSIONS</b>Sequential monitoring MRD can find out treatment outcome and adjust therapy in time.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
B-Lymphocytes
/
Treatment Outcome
/
Neoplasm, Residual
/
Diagnosis
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Flow Cytometry
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2011
Type:
Article
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