Effect of shugan jiannao tiaoyu tablets (SJTT) on hypothalamic corticotrophin releasing hormone gene expression in model rat of post-stroke depression / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2037-2040, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-252142
ABSTRACT
<p><b>OBJECTIVE</b>To study the anti-depressive mechanism of Shugan Jiannao Tiaoyu tablets (SJTT) and provide evidence for clinical application.</p><p><b>METHOD</b>Evaluate the behavioral index changes of rat model through the methods of motionless-time of swimming by force, and the consumption of sucrose, etc, meanwhile, use transmission electron microscope (TEM) to observe the cell ultrastructure and study the influence of the hypothalamic corticotrophin releasing hormone (HCRH) gene expression with the RT-PCR technique.</p><p><b>RESULT</b>SJTI could reduce the hippocampal neuronal damage caused by stress, protect the brain injury of the depressive rats. SJTT could down-regulate model rats' HCRH. Compared with the model group (P < 0.05), which indicates that SJTT could inhibit the hyperfunction of HPA Axis by down-regulating model rats' HCRH, to achieve the antidepressant effect.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Corticotropin-Releasing Hormone
/
Drugs, Chinese Herbal
/
Gene Expression Regulation
/
Rats, Sprague-Dawley
/
Reverse Transcriptase Polymerase Chain Reaction
/
Microscopy, Electron, Transmission
/
Depression
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article
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