Studies of betuionic acid on cell cycle and related protein expressions on mice of bearing H22 tumor cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1739-1743, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-252232
ABSTRACT
<p><b>OBJECTIVE</b>To study the betulonic acid on the cell cycle and related protein expressions on mice of bearing H22 tumor cells.</p><p><b>METHOD</b>Flow cytometray was used to observe the changes of betulonic acid on the cell cycle and P53 of H22 tumor cells. Immunohistochemistry was determined the espressions of PI3K and AKT.</p><p><b>RESULT</b>Increasing the doses of betulonic acid, the number of H22 cells in S phase and G2 phase was increasing gradually, it can speculate that when the betulonic acid act on cells, the cells were blocked in S and G2 phase and inhibited the protein expressions of PI3K and AKT.</p><p><b>CONCLUSION</b>Betulonic acid may be up-regulate the activity of P53 and inhibite the expressions of PI3K and AKT, so that it inhibited the survival pathway of tumor cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Immunohistochemistry
/
Cell Cycle
/
Cell Survival
/
Chemistry
/
Gene Expression Regulation
/
G2 Phase
/
Tumor Suppressor Protein p53
/
Phosphatidylinositol 3-Kinases
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article
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