Study on association between the expression of galectin- 3 and the peritoneal metastasis in gastric cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 151-154, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-252447
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the expression of galectin- 3 protein and peritoneal metastasis in gastric cancer.</p><p><b>METHOD</b>The expressions of galectin- 3 was detected in matching- samples including primary gastric cancer lesions,lymph node metastases,peritoneal metastases and paratumor normal tissues by immunohistochemistry. All specimens were gained from 35 patients who had synchronous peritoneal metastasis from gastric cancer.</p><p><b>RESULTS</b>The over- expression of galectin- 3 was observed in 97% (34/35) of the gastric cancer lesions, the peritoneal metastases and the lymph node metastases,whereas in 14% (5/35) of paratumor normal tissues. There were significant differences in the expression of galectin- 3 between paratumor normal tissues and the gastric carcinoma lesions,peritoneal metastases and lymph node metastases (P< 0.05),but there were no significant differences among the gastric cancer lesions,the peritoneal metastases,and the lymph node metastases (P> 0.05).</p><p><b>CONCLUSION</b>The expression of galectin- 3 in gastric cancer lesions can be used as a biological marker of peritoneal metastasis from gastric cancer before operation and as a prognostic factor of gastric cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Peritoneal Neoplasms
/
Stomach Neoplasms
/
Immunohistochemistry
/
Galectin 3
/
Lymph Nodes
/
Lymphatic Metastasis
/
Metabolism
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2005
Type:
Article
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