Preoperative chemoradiotherapy as neoadjuvant therapy for 35 patients with locally advanced lower rectal carcinoma / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 125-128, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-252455
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of combined preoperative chemotherapy with radiotherapy on locally advanced lower rectal carcinoma.</p><p><b>METHODS</b>Thirty- five patients with locally advanced lower rectal carcinoma were received a new regimen of combined preoperative chemotherapy with radiotherapy. Routine fr action of radiation was given with total dose of 46 Gy,2 Gy per fraction,five ti mes a week. Patients received oxaliplatin 130 mg/m(2) (infusion) on day 1, plus leu novorin 200 mg/m(2) and 5- FU 500 mg/m(2)(intravenous bolus) from day 1 to day 3 eve ry 3 weeks for total two cycles before irradiation. Operation was performed 4 to 6 weeks later after neoadjuvant therapy.</p><p><b>RESULTS</b>After neoadjuvant therapy,all patients underwent surgical resection with complete pathologic response in 7 patients,average tumor size decrease of in 34.4%, tumor stage decrease in 65.7% o f patients and nodal- negative change rate of 55.6%. Radical resection was per formed in 34 patients,in whom 18 patients received abdominoperineal resection(AP R) and 16 patients received sphincter- preserving surgery with 45.7% of anal preservation rate. One patient received palliative resection. No local recurrence occurred in all patients who received radical resection,but two cases had liver metastasis.</p><p><b>CONCLUSION</b>Combined preoperative chemotherapy with radiotherapy is a better neoadjuvant therapy for lower advanced rectal cancer,which can decrease tumor stage,improve resectability and anal sphincter preservation rate,therefore ,this new neoadjuvant therapy with tolerable toxicity will has a promising application in the clinical setting.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Rectal Neoplasms
/
General Surgery
/
Therapeutics
/
Follow-Up Studies
/
Treatment Outcome
/
Chemotherapy, Adjuvant
/
Radiotherapy, Adjuvant
/
Neoadjuvant Therapy
/
Neoplasm Staging
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS