Clinical effects of dalitong granule combined proton pump inhibitors on gastroesophageal reflux disease / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 464-467, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-252490
ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical effects of Dalitong Granule (DG) combined proton pump inhibitors (PPI) on gastroesophageal reflux disease (GERD).</p><p><b>METHODS</b>Totally 186 patients with GERD were randomly assigned to three groups, i.e., the control group A (61 cases, only PPI group, Rabeprazole Capsule 20 mg, once daily), the control group B (61 cases, PPI with domperidone group, Rabeprazole 20 mg, once daily; Domperidone 10 mg each time, thrice daily), and the experimental group (64 cases, PPI + DG group, Rabeprazole 20 mg, once daily; DG, 6 g each time, thrice daily). The treatment lasted for 4 weeks for all. The symptom scoring, the overall efficacy, local efficacy, and adverse drug reactions were compared among the three groups before and after treatment.</p><p><b>RESULTS</b>Totally 183 patients completed the experiment. After 4 weeks of treatment, the symptom scores in the three groups were significantly lowered. It was the lowest in the experimental group with statistical difference (P < 0.01). The markedly effective rate and the effective rate of the experimental group were significantly higher than those of the control A and B groups. The local markedly effective rate and the effective rate of the reflux esophagitis (RE) in the experimental group were significantly higher than those of the control A and B groups (P<0.05). No serious adverse reactions occurred in the three groups during the treatment period.</p><p><b>CONCLUSION</b>DG combined PPI could improve the symptoms of GERD safely and effectively.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Gastroesophageal Reflux
/
Treatment Outcome
/
Therapeutic Uses
/
Drug Therapy
/
Proton Pump Inhibitors
/
Integrative Medicine
/
Rabeprazole
/
Phytotherapy
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2012
Type:
Article
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