Crosstalk between canonical TGF-β/Smad and Wnt/β-catenin signaling pathway / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 591-596, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-252584
ABSTRACT
TGF-β signaling pathway plays a central role in the signaling networks that control the growth, differentiation of the cell, and the initiation of fibrosis and cancer. Wnt signaling pathway is critical for the embryonic development and the invasion and migration of cancer cells. TGF-β signaling and Wnt signaling, both of which play an important role in regulating embryonic development, fibrotic disease and tumor progression, have a close relationship. Researches find several typical cross points between these two signaling systems, such as Smad, Axin, Dvl and β-catenin. In this review, we focus on the crosstalk between TGF-β signaling and Wnt signaling through these typical factors, intending to better understand the process of fibrosis and tumor progression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Fibrosis
/
Signal Transduction
/
Transforming Growth Factor beta
/
Wnt Proteins
/
Wnt Signaling Pathway
/
Metabolism
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2013
Type:
Article
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