Bone alkaline phosphatase and N-MID osteocalcin in monitoring of osteoporosis treatment with recombinant human parathyroid hormone 1-34 / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 578-582, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-252586
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the application of bone turnover markers bone alkaline phosphatase (BALP) and N-MID osteocalcin (N-MID) in monitoring of osteoporosis treatment with recombined parathyroid hormone 1-34 (rhPTH1-34).</p><p><b>METHODS</b>The bone mineral density (BMD) of the lumbar spine L2-L4 and the proximal femur were examined by dual energy X-ray absorptiometry (DXA) before and 6 and 12 months after rhPTH 1-34 treatment. Meanwhile, serum levels of BALP and N-MID were detected by electro-chemiluminescence assay.</p><p><b>RESULTS</b>Six months after rhPTH 1-34 treatment, the BMD of proximal femur remained unchanged, and the BMD of the lumbar L2-L4 spine increased from 0.753 g/cm(2) to 0.781 g/cm(2) (P<0.05); while serum levels of N-MID increased from 15.46 ng/ml to 27.07 ng/ml(P<0.01), BALP from 14.05 μg/ml to 24.31 μg/ml(P<0.01). Twelve months after drug administration, no significant changes were observed in BMD of proximal femur, and the BMD of the lumbar spine L2-L4 increased from 0.753 g/cm(2) to 0.807 g/cm(2)(P<0.01) while serum levels of N-MID and BALP increased from 15.46 ng/ml and 14.05μg/ml to 49.38 ng/ml and 33.99 μg/ml, respectively (both P<0.01).</p><p><b>CONCLUSION</b>Serum levels of BALP and N-MID are more sensitive than BMD. Combination of two methods may provide better indicators for monitoring of osteoporosis treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Parathyroid Hormone
/
Blood
/
Recombinant Proteins
/
Diagnostic Imaging
/
Radiography
/
Bone Density
/
Osteocalcin
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Diagnostic study
Limits:
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2013
Type:
Article
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