Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians / 浙江大学学报·医学版

ABSTRACT

RF-amide related peptide (RFRP) is the orthologue of gonadotropin-inhibitory hormone (GnIH) in mammals. The bodies of RFRP cell are located in the dorsomedial nucleus of the hypothalamus (DMH) and the fibers project to preoptic area (POA) and median eminence of the hypothalamus. Its receptor mainly distributes in hypothalamus. RFRP fibers project to GnRH cells to regulate mammalian reproduction axis. This paper reviews the progress of current researches on RFRP in regulation of animal behaviors, including reproduction, food intake, anxiety and stress response.