Research advances on the roles of nicotinamide phosphoribosyltransferase in inflammation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 234-239, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-252677
ABSTRACT
Nicotinamide phosphoribosyltransferase (Nampt) is also called visfatin or pre-B-cell colony-enhancing factor. The functions of Nampt have been reported as a cytokine, an adipokine and the rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis. As a pleiotropic multifunctional protein, Nampt is involved in a variety of physiological and pathological conditions including innate immunity, metabolic disorders, and stress; and Nampt also participates in inflammatory disorders such as acute lung injury, atherosclerosis, myocardial infarct, obesity, type 2 diabetes, and rheumatoid arthritis. The studies indicate that Nampt might be a potential target for pharmacological intervention against inflammatory diseases. We review research advances on the roles of Nampt in inflammation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Nicotinamide Phosphoribosyltransferase
/
Inflammation
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2014
Type:
Article
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