Study on visual evoked related potentials in young adults of different COMT genotypes by using a numeric working memory task / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 479-482, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-252735
ABSTRACT
<p><b>AIM</b>To explore the change of number working memory ability in healthy young adults, a continuous 3-back number working memory task were performed for an hour and 12 Blocks according to different COMT genotypes of young adults.</p><p><b>METHODS</b>18 different genotype subjects were chosen from 112 healthy young adults, P3 event-related potentials was utilized to observe the relationship between this COMT polymorphism and cortical physiology in a continuous working memory task.</p><p><b>RESULTS</b>Subjects bearing the Val/Val homozygote had significantly higher mean P3 amplitudes than Val/Met heterozygote (P < 0.01), however, no significant differences in comparison to Met/Met homozygote.</p><p><b>CONCLUSION</b>Val/Met Heterozygote subjects are associated with the poorest performance of working memory. There is a relationship between COMT genotype and P3 visual event-related potentials evoked from 3-back task.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Polymorphism, Genetic
/
Brain
/
Catechol O-Methyltransferase
/
Event-Related Potentials, P300
/
Evoked Potentials, Visual
/
Genetics
/
Genotype
/
Memory, Short-Term
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2008
Type:
Article
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