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The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats / 中国应用生理学杂志
Article in Chinese | WPRIM | ID: wpr-252736
Responsible library: WPRO
ABSTRACT
<p><b>AIM</b>To study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.</p><p><b>METHODS</b>SD rats were divided into three groups Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.</p><p><b>RESULTS</b>There was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.</p><p><b>CONCLUSION</b>Ang-(1-7) can relieve the renal process of diabetic rats.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Peptide Fragments / Pharmacology / Rats / Male / Platelet-Derived Growth Factor / RNA, Messenger / Angiotensin I / Rats, Sprague-Dawley / Diabetes Mellitus, Experimental Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Peptide Fragments / Pharmacology / Rats / Male / Platelet-Derived Growth Factor / RNA, Messenger / Angiotensin I / Rats, Sprague-Dawley / Diabetes Mellitus, Experimental Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2008 Type: Article