Epididymal cyst in von Hippel-Lindau syndrome: clinicopathologic analysis of 3 cases / 中华男科学杂志
National Journal of Andrology
;
(12): 142-145, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-252806
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinicopathologic features of epididymal cyst in von Hippel-Lindau (VHL) syndrome.</p><p><b>METHODS</b>We reviewed the clinical data of 3 epididymal cyst patients treated by surgery, and detected the expressions of HIF-1alpha, VEGF, alpha-SMA and CD34 in the epididymal tissue samples by the immunohistochemistry SP method.</p><p><b>RESULTS</b>All the 3 patients underwent surgical removal of the epididymal cyst. Immunohistochemistry of the epididymal tissues showed HIF-1alpha, VEGF, alpha-SMA and CD34 to be positive. All the 3 cases were confirmed to be VHL syndrome, 1 right after surgery, and the other 2 within 8 years postoperatively.</p><p><b>CONCLUSION</b>Epididymal cyst is a usual benign disease, which may occur independently of or be complicated by VHL syndrome. If immunohistochemistry of epididymal tissues shows HIF-1alpha, VEGF, alpha-SMA and CD34 to be positive, VHL syndrome should be considered, and further clinical examinations and post-operation follow-up are necessitated.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Spermatocele
/
Actins
/
Vascular Endothelial Growth Factor A
/
Epididymis
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Von Hippel-Lindau Disease
/
Metabolism
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2010
Type:
Article
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