Expressions of neurotrophic factors and their receptors in prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 129-131, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-252809
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of neurotrophic factors (NTFs) and their receptors in prostate cancer.</p><p><b>METHODS</b>We detected the expressions of the nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and their receptors TrkA, TrkB and p75 in 35 specimens of prostate cancer by Western blotting, and included 10 specimens of normal prostate tissue from young males that died accidentally.</p><p><b>RESULTS</b>Compared with the control group, the expressions of NGF and p75 were significantly decreased (P < 0.01), while those of BDNF, TrkA and TrkB significantly increased in prostate cancer (P < 0.05).</p><p><b>CONCLUSION</b>The changes in the expressions of NTFs and their receptors were related with the pathogenesis and progression of prostate cancer, which may be considered as reference indexes for the diagnosis of the disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatic Neoplasms
/
Case-Control Studies
/
Brain-Derived Neurotrophic Factor
/
Receptor, trkA
/
Receptor, trkB
/
Receptor, Nerve Growth Factor
/
Metabolism
/
Nerve Growth Factors
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2010
Type:
Article
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