M. tuberculosis Somatic Antigen Specific CD8+T cell Responses in BCG-Vaccinated Subjects / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 272-278, 2005.
Article
in Korean
| WPRIM
| ID: wpr-25286
ABSTRACT
BACKGROUND:
The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects.METHODS:
Cytotoxicity and IFN-gamma elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects.RESULTS:
The results indicate the cytotoxic and IFN-gamma immune responses of CD8+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects.CONCLUSION:
The cytotoxic and IFN-gamma responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tuberculosis
/
Enzyme-Linked Immunospot Assay
/
Mycobacterium bovis
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2005
Type:
Article
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