Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis / 中华男科学杂志
National Journal of Andrology
;
(12): 84-88, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-252868
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of curcumin on the expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis.</p><p><b>METHODS</b>Sixty healthy adult male SD rats with the body weight of 200 -220 g were equally and randomly divided into a normal control, a positive control, a model, an oral curcumin and an intraperitoneal curcumin group. The rat models of chronic nonbacterial prostatitis were made by hypodermic injection of estradiol benzoate at the dose of 0.25 mg/(kg x d) for 30 days after castration, and then treated with curcumin at 200 mg/(kg x d) by gavage or intraperitoneal injection. The positive controls received oral celebrex at 250 mg/(kg x d), while the normal control and model groups were given saline by gavage. After a week of treatment, the levels of TNF-alpha, IL-6 and IL-8 in the serum and prostate tissues of the rats were detected by ELISA assay.</p><p><b>RESULTS</b>The levels of TNF-alpha and IL-8 in the serum and prostate tissues were significantly lower in the intraperitoneal curcumin than in the positive control group (P < 0.05), but the expression of IL-6 showed no significant difference between the two groups (P > 0.01).</p><p><b>CONCLUSION</b>Curcumin is efficacious for chronic nonbacterial prostatitis in rats, and the action mechanism may be associated with its decreasing effect on the proinflammatory cytokines IL-8 and TNF-alpha in the blood and tissues.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Prostatitis
/
Drugs, Chinese Herbal
/
Chronic Disease
/
Interleukin-8
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Rats, Sprague-Dawley
/
Curcumin
/
Therapeutic Uses
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2010
Type:
Article
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