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Pharmacokinetics of ginkgolides sustained-release tablet / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1011-1014, 2011.
Article in Chinese | WPRIM | ID: wpr-252953
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics and bioavailability of ginkgolides sustained-release tablet and conventional tablet in Beagle dogs.</p><p><b>METHOD</b>The concentrations of ginkgolides in plasma were determined by LC-MS. The main pharmacokinetic parameters of ginkgolides sustained-release tablet and conventional tablet in vivo were obtained using Pharmacokinetic software DAS 2.0.</p><p><b>RESULT</b>The C(max) of grinkgolide A in ginkgolide sustained-release tablet and conventional tablet were 443.51, 1 039.30 microg x L(-1), respecitvely. t(max) were 2.92, 1.08 h, respectively. AUC(0-12h) were 1 808.21, 2 041.37 h x microg(-1) x L(-1), respectively. MRT were 5.18, 3.18 h, respectively. The relative bioavailability of ginkgolides A was 88.58%. The C(max) of ginkgolide B in ginkgolide sustained-release tablet and conventional tablet were 407.13, 547.38 microg x L(-1), respectively. t(max) were 2.92, 1.08 h, respectively. AUC(01-12 h) were 1 987.31, 1 748.04 h x microg(-1) x L(-1), respectively. MRT were 6.05, 4.98 h, respectively. The relative bioavailability of ginkgolides B was 113.69%.</p><p><b>CONCLUSION</b>The ginkgolides sustained-release tablets have good sustained release characteristics and are bioequivalent to the reference formulation.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Mass Spectrometry / Tablets / Pharmacokinetics / Biological Availability / Therapeutic Equivalency / Chromatography, High Pressure Liquid / Area Under Curve / Delayed-Action Preparations / Ginkgolides Type of study: Prognostic study Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Mass Spectrometry / Tablets / Pharmacokinetics / Biological Availability / Therapeutic Equivalency / Chromatography, High Pressure Liquid / Area Under Curve / Delayed-Action Preparations / Ginkgolides Type of study: Prognostic study Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2011 Type: Article