A novel method for fast determination of components in Guizhi Fuling capsule by near infrared spectroscopy / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1004-1006, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-252955
ABSTRACT
<p><b>OBJECTIVE</b>To develop a new method to rapidly determine and identify Guizhi Fuling capsule by portable acousto-optic tunable filter-near infrared spectroscopy.</p><p><b>METHOD</b>The qualitative model was set up using principal component analysis. The correlation models between the NIR spectra and the reference values of five major constituents were obtained with partial least squares method.</p><p><b>RESULT</b>The identifying model accurately identified Guizhi Fuling capsule, and quantitative analytical models could precisely predicted the content of ellagic acid, baicalin, benzoylpaenoniflorin, cinnamaldehyde, and paeonol. The correlation coefficients of the calibration models were 0.924 2, 0.938 4, 0.924 2, 0.933 6, 0.934 7, the validation set coefficients of the calibration were 0.924 2, 0.938 4, 0.924 2, 0.933 6, 0.934 7, and the RMSEP were 1.138%, 3.014%, 0.751%, 0.625%, 3.455%, 1.363%, respectively. The results of external validation showed no significant difference between the predictive and the determining values by t-test.</p><p><b>CONCLUSION</b>The method is accurate, rapid and non-destructive, and can be used for determining and identifying Guizhi Fuling capsule.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Acetophenones
/
Flavonoids
/
Acrolein
/
Calibration
/
Capsules
/
Drugs, Chinese Herbal
/
Least-Squares Analysis
/
Chemistry
/
Spectroscopy, Near-Infrared
/
Principal Component Analysis
Type of study:
Prognostic study
/
Qualitative research
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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