Effects of glycyrrhiza extract on pharmacokinetics property of daphnetin in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 935-938, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-252969
ABSTRACT
<p><b>OBJECTIVE</b>To research the influence of glycyrrhiza extract on the pharmacokinetics characteristic parameters of daphnetin, which was aimed to explore the rationality of concert application of drugs.</p><p><b>METHOD</b>The rats received intragastric administration of daphnetin and glycyrrhiza extract containing the same daphnetin respectively. The blood concentration of daphnetin was assayed by LC-MS. The data was processed by program DAS2.1.1.</p><p><b>RESULT</b>Glycyrrhiza extract can reduce the t(1/2), tmax and Ke of daphnetin, while increased the Ka and AUC(0-infinity).</p><p><b>CONCLUSION</b>Glycyrrhiza extract promoted the oral absorption of daphnetin, slowed down the elimination and increased the biological availability.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Umbelliferones
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Tissue Distribution
/
Chemistry
/
Rats, Sprague-Dawley
/
Drug Interactions
/
Glycyrrhiza
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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