Proliferation and Apoptosis in Prostatic Hypertrophy / 대한비뇨기과학회지

ABSTRACT

PURPOSE: Volumetric change of prostate is the result of unbalanced proliferation and apoptosis. We investigated the characteristics of proliferation and apoptosis in hypertrophic prostate. MATERIALS AND METHODS: Proliferative and apoptotic rates were quantitated with immunoprofiles of proliferative cell nuclear antigen(PCNA) and apoptotic body with 46 paraffin-embeded BPH specimen. When the rate of proliferation was higher than that of apoptosis, we defined as proliferation active group. RESULTS: Proliferation and apoptotic rates of stromal and epithelial cells were 4.5%, 2.9% and 1.9%, 1.1%, respectively(p 0.05). CONCLUSIONS: These results demonstrate that stromal proliferation is the main cause of prostatic hypertrophy. The unbalance between proliferation and apoptosis of prostatic cells seems to be unsteady in time.