Effect of AcSDKP on the proliferation and collagen synthesis in cultured rat cardiac fibroblasts stimulated by PDGF / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 66-69, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-253084
ABSTRACT
<p><b>AIM</b>To investigate whether AcSDKP can inhibit proliferation and collagen synthesis in cultured rat cardiac fibroblasts mediated by PDGF.</p><p><b>METHODS</b>Neonatal rat cardiac fibroblasts were isolated. The cell proliferation was observed by 3H-proline incorporation assay.</p><p><b>RESULTS</b>On the culture of 0.4% FBS, PDGF stimulated cardiac fibroblasts proliferation and collagen synthesis with a dose-dependent manner at the concentrations from 1 ng/ml to 20 ng/ml, in which 10 ng/ml PDGF reached its peak. AcSDKP at the concentration from 10(-10) mol/L to 10(-8) mol/L could inhibit cardiac fibroblasts proliferation and collagen synthesis mediated by PDGF. 10(-9) mol/L AcSDKP attained its peak on inhibiting cardiac fibroblasts proliferation and collagen synthesis.</p><p><b>CONCLUSION</b>AcSDKP can inhibit proliferation and collagen synthesis in cultured rat cardiac fibroblasts mediated by PDGF.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligopeptides
/
Pharmacology
/
Platelet-Derived Growth Factor
/
Cells, Cultured
/
Collagen
/
Rats, Wistar
/
Cell Biology
/
Myoblasts, Cardiac
/
Cell Proliferation
/
Fibroblasts
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2007
Type:
Article
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