Effects of soybean isoflavones on the cell cycles, the cell apoptosis and the proliferation of spleen in radiated mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 497-500, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-253105
ABSTRACT
<p><b>AIM</b>To study effect of soybean isoflavones (SI) on spleen in radiated mice.</p><p><b>METHODS</b>90 male mice were randomly divided into control group, radiated group, radiated plus 0.5% dose SI group. After 2-week feeding, the mice received 4.0 Gy 137Cs gamma-radiation, the cell cycles, cell apoptosis and proliferation on the spleen and the spleen index were observed in radiated after 12 h, 24 h, 1 week and 2 weeks.</p><p><b>RESULTS</b>After the mice were radiated, the spleen were significantly atrophy, the rate of the cell apoptosis and the cell cycles of G0-G1 phase in splenocytes were significantly increased (P < 0.01), the cell cycles rate of S phase and the proliferation index were significantly decreased in spleen (P < 0.05). Compared with radiated group, the spleen atrophy and the rate of the cell cycles of G0-G1 phase were significantly decreased (P < 0.05), and the cell cycles of G2-M phase and the proliferation index were significantly increased (P < 0.05) in the mice supplied 0.5% soybean isoflavones.</p><p><b>CONCLUSION</b>The soybean isoflavones could significantly increase spleen radioprotective effect in mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Radiation Effects
/
Radiation, Ionizing
/
Glycine max
/
Spleen
/
Cell Cycle
/
Apoptosis
/
Cellular Structures
/
Cell Biology
/
Isoflavones
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2006
Type:
Article
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