A study on the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 334-337, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-253150
ABSTRACT
<p><b>AIM</b>To investigate the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia.</p><p><b>METHODS</b>In the case-control study, the gene polymorphisms of glutathione S-transferases were tested in Tibetan mountaineers and sea-level Han Chinese by multiple-PCR and PCR-RELP.</p><p><b>RESULTS</b>The frequency of GSTT1 null genotype was significant different between Tibetan mountaineers and sea-level Han Chinese (P < 0.05), OR = 1.86 (95% CI = 1.01-3.39), and also for GSTP(1-105) mutant genotype in two groups (P < 0.01), OR = 2.19 (95% CI = 1.16-4.13). There was significant difference between A allele and G allele of GSTP(1-105) groups (P < 0.01). There was no difference for GSTM1 null genotype between two groups (P > 0.05), OR = 0.78 (95% CI = 0.43 - 1.42).</p><p><b>CONCLUSION</b>GSTT1 and GSTP(1-105) genotype may be associated with susceptibility response to altitude hypoxia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
China
/
Reactive Oxygen Species
/
Alleles
/
Glutathione S-Transferase pi
/
Genetics
/
Genotype
/
Glutathione Transferase
/
Hypoxia
/
Metabolism
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2006
Type:
Article
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