Significance of id4 promoter methylation in monitoring AML patients with completely remission / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 476-478, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-253294
ABSTRACT
The study was purposed to investigate the significance of id4 gene promoter methylation in monitoring AML patients with complete remission (CR). Methylation specific-PCR (MS-PCR) were used to detect the status of promoter methylation of id4 gene in bone marrow samples from AML patients with CR who had accepted induction with DA or IA and 4 to 5 consolidation chemotherapy with Ara-C. The results showed that in the all 32 patients, 15 were found to show id4 promoter methylation and 7 out of the 15 were found relapsed or tendency to relapse in the following-up period. While all the 17 patients with id4 unmethylation were still in their CR status in the same period. In conclusion, id4 promoter methylation might be a predictor for relapse of AML patients with CR in certain degree.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Myeloid, Acute
/
Promoter Regions, Genetic
/
Neoplasm, Residual
/
DNA Methylation
/
Diagnosis
/
Inhibitor of Differentiation Proteins
/
Genetics
/
Metabolism
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2008
Type:
Article
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