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Analysis on expression and molecular basis for ABO glycosyltransferase with dual specificity / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 421-424, 2008.
Article in Chinese | WPRIM | ID: wpr-253306
ABSTRACT
In order to elucidate the expression and molecular genetic background of ABO gene seven samples with ABO discrepancy further identified as bi-specific ABO gene were studied. All these samples were subjected to phenotyping by monoclonal and polyclonal antisera and were then genotyped by direct DNA sequencing and haplotype-sequencing at the exon 6 and 7 of ABO gene. As a result, six ABO dual-specific alleles were identified in Chinese population. An antigen expressed by these B (A) or Cis-AB individuals varied from very low level to the normal level, compared with common A blood group samples. In conclusion, molecular genetic backgrounds of two pairs out of four samples in all samples were the same, however, the ABO expression showed diverse.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: ABO Blood-Group System / DNA Mutational Analysis / Chemistry / Exons / Glycosyltransferases / Cell Biology / Asian People / Erythrocytes / Genetics / Metabolism Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: ABO Blood-Group System / DNA Mutational Analysis / Chemistry / Exons / Glycosyltransferases / Cell Biology / Asian People / Erythrocytes / Genetics / Metabolism Type of study: Prognostic study Limits: Humans Language: Chinese Journal: Journal of Experimental Hematology Year: 2008 Type: Article