Analysis on expression and molecular basis for ABO glycosyltransferase with dual specificity / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 421-424, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-253306
ABSTRACT
In order to elucidate the expression and molecular genetic background of ABO gene seven samples with ABO discrepancy further identified as bi-specific ABO gene were studied. All these samples were subjected to phenotyping by monoclonal and polyclonal antisera and were then genotyped by direct DNA sequencing and haplotype-sequencing at the exon 6 and 7 of ABO gene. As a result, six ABO dual-specific alleles were identified in Chinese population. An antigen expressed by these B (A) or Cis-AB individuals varied from very low level to the normal level, compared with common A blood group samples. In conclusion, molecular genetic backgrounds of two pairs out of four samples in all samples were the same, however, the ABO expression showed diverse.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
ABO Blood-Group System
/
DNA Mutational Analysis
/
Chemistry
/
Exons
/
Glycosyltransferases
/
Cell Biology
/
Asian People
/
Erythrocytes
/
Genetics
/
Metabolism
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2008
Type:
Article
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