Effects of chronic hypoxic hypercapnia on spatial learning-memory and expression of NMDAR1 in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 434-437, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-253383
ABSTRACT
<p><b>AIM</b>To explore the effect of chronic hypoxic hypercapnia on learning-memory and the possible mechanisms involved.</p><p><b>METHODS</b>Fifty-eight male SD rats were randomly divided into three groups Normal control group (NC, n=18), 2-week (2HH, n=18), and 4-week hypoxic hypercapnia (4HH, n=20) group. The rats, spatial learning-memory tasks were assessed by the Morris water maze. The expression of NMDAR1mRNA was determined by hybridization in situ.</p><p><b>RESULTS</b>Compared with NC group, rats exposed to chronic hypoxic hypercapnia displayed significant impairment in their performance assessed by two measures:
mean escape latencies (2HH 38.59 +/- 8.35 s, 4HH 60.59 +/- 17.28 s) and swim path distances(2HH 9893.45 +/- 1958.16 mm, 4HH 18077.57 +/- 6878.85 mm). The expression level of NMDAR1mRNA in the hippocampus and cortex were lower than those in the NC group, especially, the NMDAR1mRNA expression of hippocampus CA1 in 4HH decreased by 21.4% (P < 0.01).</p><p><b>CONCLUSION</b>Chronic hypoxic hypercapnia could impair the rat spatial learning-memory and the decrease in expression of NMDAR1mRNA might be involved in.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Sprague-Dawley
/
Receptors, N-Methyl-D-Aspartate
/
Maze Learning
/
Hypercapnia
/
Memory
/
Hypoxia
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2007
Type:
Article
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