The protective effect of nicotine on dopaminergic neuron of Parkinson's disease mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 425-429, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-253385
ABSTRACT
<p><b>AIM</b>To investigate the protective effect of nicotine on dopaminergic neurons and its mechanisms in mice with Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).</p><p><b>METHODS</b>C57BL/6J mice were injected with MPTP for 8 days to establish PD model. Nicotine was given for 10 days in the pretreatment group. Animals were examined behaviorally with the pole test and traction test. Tyrosine hydroxylase (TH) and gamma-aminobutyric acid (GABA) were investigated by the immunocytochemistry (ICC) method. The ultrastructural changes of caudate nucleus(CN) were observed by electron microscope.</p><p><b>RESULTS</b>The results showed that pretreatment nicotine could improve the dyskinesia of PD mice markedly. Simultaneously, TH (P < 0.01) neurons and GABA (P < 0.05) neurons were much more in the pretreatment group when compared with those in the model group. The ultrastructural injury of the pretreatment group was also ameliorated.</p><p><b>CONCLUSION</b>Nicotine has a protective effect on the dopaminergic neurons in the MPTP-treated mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Pharmacology
/
Tyrosine 3-Monooxygenase
/
Caudate Nucleus
/
Neuroprotective Agents
/
Disease Models, Animal
/
Drug Therapy
/
Dopaminergic Neurons
/
Gamma-Aminobutyric Acid
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2007
Type:
Article
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