Effects of vitamin E on expression of PS-1 and production of Abeta in the hippocampus of female senile rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 237-240, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-253436
ABSTRACT
<p><b>AIM</b>To observe the expression of Presenilin-1 (PS-1) and production of amyloid beta-protein (Abeta) in hippocampus of female senile rats and to investigate the effect of vitamin E(VE) on preventing Alzheimer's disease after menopause.</p><p><b>METHODS</b>The animal model was established using female senile rats. Experimental groups (n=8) were respectively given different doses of VE(5 mg/kg, 15 mg/kg, 60 mg/kg) per day. The expression of PS-1 in hippocampus was detected by immunohistochemistry, the level of Abeta in hippocampus was measured by Radioimmunoassay, and neuronal ultrastructure in hippocampal DG area was observed using transmission electron microscope.</p><p><b>RESULTS</b>The expression of PS-1 in rat hippocampus of senile control group was stronger than that of adult control group. PS-1 expressed weakly in three medication groups along with augmentation of dosage. The levels of Abeta were found to correlate statistically with the expression of PS-1. The content of Abeta in VE groups was significantly decreased compared to that in senile control group (P < 0.01). There were some changes in the neuronal ultrastructure of senile rats. Neurons were gradually recovered in VE groups.</p><p><b>CONCLUSION</b>VE may depress the production of Abeta by regulating the expression of PS-1, reducing neuronal injuries. VE may play a role in neuronal protection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Vitamin E
/
Aging
/
Amyloid beta-Peptides
/
Rats, Wistar
/
Presenilin-1
/
Alzheimer Disease
/
Hippocampus
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2007
Type:
Article
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