Attenuation of Spinal Cord Injury-Induced Astroglial and Microglial Activation by Repetitive Transcranial Magnetic Stimulation in Rats
Journal of Korean Medical Science
;
: 295-299, 2013.
Article
in English
| WPRIM
| ID: wpr-25344
ABSTRACT
Spinal cord injury (SCI) causes not only loss of sensory and motor function below the level of injury but also chronic pain, which is difficult and challenging of the treatment. Repetitive transcranial magnetic stimulation (rTMS) to the motor cortex, of non-invasive therapeutic methods, has the motor and sensory consequences and modulates pain in SCI-patients. In the present study, we studied the effectiveness of rTMS and the relationship between the modulation of pain and the changes of neuroglial expression in the spinal cord using a rat SCI-induced pain model. Elevated expressions of Iba1 and GFAP, specific microglial and astrocyte markers, was respectively observed in dorsal and ventral horns at the L4 and L5 levels in SCI rats. But in SCI rats treated with 25 Hz rTMS for 8 weeks, these expressions were significantly reduced by about 30%. Our finding suggests that this attenuation of activation by rTMS is related to pain modulation after SCI. Therefore, rTMS might provide an alternative means of attenuating neuropathic pain below the level of SCI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Cord Injuries
/
Calcium-Binding Proteins
/
Immunohistochemistry
/
Astrocytes
/
Rats, Sprague-Dawley
/
Microglia
/
Disease Models, Animal
/
Transcranial Magnetic Stimulation
/
Microfilament Proteins
/
Nerve Tissue Proteins
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS