The relationship between the effects of curcumin on cerebral ischemia/reperfusion injury and immediately genic expressions of fos, Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 184-188, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-253451
ABSTRACT
<p><b>AIM</b>To explore the relationship between the effects of curcumin on cerebral ischemic/reperfusion injury and immediately genic expressions of Fos, Jun and NF-kappaB in hippocampal CA1 area.</p><p><b>METHODS</b>Gerbils were randomly divided into sham group (SH), ischemia/reperfusion group (I/R), curcumin group (CU) and solvent control group (SC). Forebrain ischemia was induced by occlusion of bilateral common carotid arteries. Observations were carried out in each group 15 min, 1 h, 2 h, 6 h, 1 d, 3 d, 5 d and 7 d after ischemia open field test was used to examine the behavioral change, the apoptosis neurons in hippocampal CA1 region was counted, the expression of Fos, Jun and NF-kappaB in hippocampal CA1 was detected by SABC immunocytochemical technique.</p><p><b>RESULTS</b>The behavioral mark and the number of apoptosis neurons in hippocampal (CA1 region was much less in CU group than in I/R group (P < 0.01) The expression of Fos was more and the expression of Jun and NF-kappaB was less in CA1 area in CU group than in I/R group (P < 0.01).</p><p><b>CONCLUSION</b>Curcumin can significantly protect neurons against cerebral ischemia, increasing the expression Fos and decreasing the expression of Jun and NF-kappaB may be the protective mechanisms.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Reperfusion Injury
/
Brain Ischemia
/
NF-kappa B
/
Gerbillinae
/
Proto-Oncogene Proteins c-jun
/
Proto-Oncogene Proteins c-fos
/
Apoptosis
/
Curcumin
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS