The absorption characteristics of silybin in small intestine of rat / 药学学报
Acta Pharmaceutica Sinica
;
(12): 138-141, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-253484
ABSTRACT
<p><b>AIM</b>To investigate the intestinal absorption of silybin (SLB) in male rats.</p><p><b>METHODS</b>Single-pass intestinal perfusion (SPIP) technique was performed in each isolated region of the small intestine at a flow rate of 0.1 mL x min(-1). The samples of perfusate and portal plasma were collected at the designated periods of time after rat intestinal perfusion and analyzed for drug by HPLC.</p><p><b>RESULTS</b>The absorption rate constant (k(a)) and the effective permeability (P(eff)) of SLB at 190 microg x mL(-1) were determined for each segment. These data indicated the absorption rate were duodenum > jejunum > ileum > colon. SPIP was also performed in duodenum with three concentrations of SLB (80, 190 and 300 microg x mL(-1)). The concentration dependent changes of k(a) and P(eff) were evident in the duodenum perfusion of silybin. At silybin perfusate concentrations of 80 microg x mL(-1), k(a) and P(eff) were different from the values at either of the two higher concentrations (190 and 300 microg x mL(-1), P < 0.05). However there was no difference between 190 microg x mL(-1) and 300 microg x mL(-1) groups. The drug mass appearing in the plasma further indicated the absorption were duodenum > jejunum > ileum > colon.</p><p><b>CONCLUSION</b>SLB can be absorbed in whole intestinal sections. When the concentration raises to a certain level, the uptake of SLB will not increase.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Plants, Medicinal
/
Silymarin
/
Blood
/
Pharmacokinetics
/
Chemistry
/
Rats, Sprague-Dawley
/
Colon
/
Silybum marianum
/
Duodenum
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2006
Type:
Article
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