Profile-effect on quality control of Houttuynia cordata injection / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1147-1150, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-253513
ABSTRACT
<p><b>AIM</b>To find corresponding relationship between the fingerprint of Houttuynia cordata injections from different factories and their effects.</p><p><b>METHODS</b>Houttuynia cordata injections from six different factories were determined by gas chromatography (GC) and gas chromatography-mass spectra (GC-MS), and GC fingerprints were classified by hierarchical clustering. The anti-inflammatory activity of Houttuynia cordata injections was characterized through the rat pleurisy model induced by carrageenin and the mice ear edema model by dimethylbenzene.</p><p><b>RESULTS</b>The anti-inflammatory effect of the injections from the first class factories on the two model was significant, while those from the second class not. GC-MS analysis result indicated that main effect compounds in Houttuynia cordata injections are methyl n-nonyl ketone, decanoylacetaldehyde, lauryl aldehyde, capryl aldehyde, beta-pinene, beta-linalool, 1-nonanol, 4-terpineol, alpha-terpineol, bornyl acetate, n-decanoic acid and acetic acid, geraniol ester etc.</p><p><b>CONCLUSION</b>There is corresponding relationship between the fingerprint of Houttuynia cordata injections and effect to a certain extent.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Pleurisy
/
Quality Control
/
Xylenes
/
Drugs, Chinese Herbal
/
Carrageenan
/
Chemistry
/
Anti-Inflammatory Agents, Non-Steroidal
/
Rats, Wistar
/
Therapeutic Uses
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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