Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1122-1126, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-253519
ABSTRACT
<p><b>AIM</b>To design and synthesize new compounds of prandial glucose regulator with more simple structure.</p><p><b>METHODS</b>The target compounds were synthesized from diethyl succinate and benzaldehyde or 4-fluorobenzaldehyde by four-step reactions. Thus 18 compounds were synthesized. Their structures were comfirmed by NMR, MS and IR.</p><p><b>RESULTS</b>Seventeen compounds had different hypoglycemic activity in mice, among them, 9 compounds had higher hypoglycemic activity and 6 compounds had character of prandial glucose regulator.</p><p><b>CONCLUSION</b>Part of the compounds have higher hypoglycemic activity deserve to be further investigated.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phenylalanine
/
Piperidines
/
Structure-Activity Relationship
/
Succinates
/
Benzylidene Compounds
/
Blood Glucose
/
Carbamates
/
Molecular Structure
/
Chemistry
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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