Synthesis and antitumour activity of metal complexes of bacteriochlorophyll / 药学学报

ABSTRACT

<p><b>AIM</b>To find a new PDT sensitizer.</p><p><b>METHODS</b>There were four complexes (Cu, Zn, Co, Ni) synthesized through reaction of metal and deprivating-Mg bacteriochlorophyll in the organic solvent. Their antitumor action was detected by MTT.</p><p><b>RESULTS</b>The ultraviolet-visual spectrum and the fluorescence spectrum of these complexes showed that synthesis of these four complexes was succeeded. And these metal complexes have potent antitumor action on two kinds of leukaemic cells.</p><p><b>CONCLUSION</b>Metal bacteriochlorophylls as PDT sensitizers have very good properties and this is a way to develop new PDT sensitizers.</p>