Isolation and identification of two new epimer from the mother liquid of megestrol acetate / 药学学报
Acta Pharmaceutica Sinica
;
(12): 830-833, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-253559
ABSTRACT
<p><b>AIM</b>To study the impurity in the drug megestrol acetate.</p><p><b>METHODS</b>Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis.</p><p><b>RESULTS</b>Two new epimers were isolated from the mother liquid of the drug megestrol acetate.</p><p><b>CONCLUSION</b>These new epimers were identified as 17alpha-acetoxy-2beta,6alpha-dimethylprega-4-ene-3,20-dione (1) and 17alpha-acetoxy-2alpha,6alpha-dimethylprega-4-ene-3,20-dione (2).</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnanediones
/
Stereoisomerism
/
Molecular Structure
/
Chemistry
/
Drug Contamination
/
Megestrol Acetate
/
Molecular Conformation
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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