Design and synthesis of quinoxaline derivatives and their antitumor activities / 药学学报
Acta Pharmaceutica Sinica
;
(12): 814-819, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-253562
ABSTRACT
<p><b>AIM</b>To design and synthesize novel quinoxaline derivatives as antitumor agents.</p><p><b>METHODS</b>Using 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives.</p><p><b>RESULTS</b>The structures of the target molecules were characterized by elemental analysis, 1H NMR, MS, and IR.</p><p><b>CONCLUSION</b>At concentration of 1 x 10(-4) mol x L(-1), some of the derivatives showed equal antitumor activities to XK469.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Quinoxalines
/
Molecular Structure
/
Chemistry
/
Cell Line, Tumor
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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