Stereoselective pharmacokinetics of tetrahydropalmatine in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 746-749, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-253576
ABSTRACT
<p><b>AIM</b>To investigate the stereoselective pharmacokinetic process of tetrahydropalmatine (THP) in rats.</p><p><b>METHODS</b>The concentrations of tetrahydropalmatine enantiomers in rat plasma were determined by coupled achiral and chiral HPLC method. The differences in plasma concentrations and pharmacokinetic parameters between the two enantiomers were compared by paired t-test.</p><p><b>RESULTS</b>The plasma levels of l-THP were always higher than those of d-THP in eight rats. There was significant difference between the main pharmacokinetic parameters of the two enantiomers.</p><p><b>CONCLUSION</b>Tetrahydropalmatine showed significant stereoselective pharmacokinetics in rats after an ig dose of the racemate.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Stereoisomerism
/
Berberine Alkaloids
/
Pharmacokinetics
/
Molecular Structure
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Rats, Sprague-Dawley
/
Area Under Curve
/
Corydalis
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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