Antitumor effects of electrothermal and electrochemical therapy on mice with sarcoma180 / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the anti-tumor effects and the mechanism of a new treatment for Sarcoma180 in mice using both hyperthermia (H) and electrochemical therapy (ECT).</p><p><b>METHODS</b>A group of mice with Sarcoma180 (1 cm in diameter) were divided randomly into four groups and given different treatments Control, ECT alone, H alone and electrothermal & electrochemical therapy (ETECT). The volumes of the tumors were calculated everyday after treatment. The tumor tissues were examined morphologically at 0, 6, 24 and 72 hours after treatment.</p><p><b>RESULTS</b>The tumors treated with ETECT were completely destroyed, and did not recur within a period of ten days by pathological examination. Results of this group were significantly different with the other groups (P<0.01). However, recurred tumors were found in 6 mice of H group and 5 mice of ECT group, respectively.</p><p><b>CONCLUSIONS</b>Based on the results obtained, ETECT induced by ETECD (D-device) is an effective way to eliminate cancer. It is capable of completely destroying cancer cells in a short time. The rate of Sarcoma180 inhibition is 100%, and malignant cells can't recur. The research provided theoretical and experimental bases for the treatment of oral cancer by a new approach to treat oral cancer.</p>