Oxidative stress in testicular tissues of rats exposed to cigarette smoke and protective effects of caffeic acid phenethyl ester / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 189-193, 2006.
Article
in English
| WPRIM
| ID: wpr-253859
ABSTRACT
<p><b>AIM</b>To show the oxidative stress after cigarette smoke exposure in rat testis and to evaluate the effects of caffeic acid phenethyl ester (CAPE).</p><p><b>METHODS</b>Twenty-one rats were divided into three groups of seven. Animals in Group I were used as control. Rats in Group II were exposed to cigarette smoke only (4 x 30 min/d) and rats in Group III were exposed to cigarette smoke and received daily intraperitoneal injections of CAPE (10 micromol/kg x d). After 60 days all the rats were killed and the levels of nitric oxide (NO) and anti-oxidant enzymes such as superoxide-dismutase, catalase and glutathione peroxidase (GSH-Px) and the level of malondialdehyde were studied in the testicular tissues of rats with spectrophotometric analysis.</p><p><b>RESULTS</b>There was a significant increase in catalase and superoxide-dismutase activities in Group II when compared to the controls, but the levels of both decreased after CAPE administration in Group III. GSH-Px activity was decreased in Group II but CAPE caused an elevation in GSH-Px activity in Group III. The difference between the levels of GSH-Px in Group I and Group II was significant, but the difference between groups II and III was not significant. Elevation of malondialdehyde after smoke exposure was significant and CAPE caused a decrease to a level which was not statistically different to the control group. A significantly increased level of NO after exposure to smoke was reversed by CAPE administration and the difference between NO levels in groups I and III was statistically insignificant.</p><p><b>CONCLUSION</b>Exposure to cigarette smoke causes changes in the oxidative enzyme levels in rat testis, but CAPE can reverse these harmful effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylethyl Alcohol
/
Physiology
/
Superoxide Dismutase
/
Testis
/
Caffeic Acids
/
Smoking
/
Catalase
/
Rats, Wistar
/
Oxidative Stress
/
Therapeutic Uses
Limits:
Animals
Language:
English
Journal:
Asian Journal of Andrology
Year:
2006
Type:
Article
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