Correlation between serum HER-2 oncoprotein and patients with breast cancer / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 212-215, 2004.
Article
in English
| WPRIM
| ID: wpr-253987
ABSTRACT
<p><b>OBJECTIVE</b>To detect serum HER-2 oncoprotein levels in patients with operable and metastatic breast cancers, and to study the correlations between serum HER-2 level and lymph node status as well as other clinical parameters.</p><p><b>METHODS</b>A total of 120 women were studied consisting of 10 healthy volunteers, 31 benign breast disease, 53 operable breast cancer, and 26 metastatic breast cancer patients. The levels of serum HER-2 were measured using an enzyme-liked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The mean serum HER-2 levels were 9.6 +/- 1.5 ng/mL in healthy volunteers, 11.9 +/- 1.6 ng/mL in benign breast disease, 13.2 +/- 4.2 ng/mL in operable breast cancer, and 30.5 +/- 30.8 ng/mL in metastatic breast cancer patients. The former is much lower than the latter three (P = 0.02, 0.001, 0.03, respectively). If using 15 ng/mL as a normal baseline, elevated serum HER-2 levels were observed in none of the healthy volunteers as well as patients with benign disease, but in 18.9% (10/53) operable breast cancer patients and 61.5% (16/26) metastatic patients. In patients with operable breast cancer, there was a positive correlation between serum concentrations of HER-2 and the size of primary tumor (P < 0.05), whereas there was no correlation between serum concentration and axillary lymph node or estrogen receptor status. In patients with metastatic disease, there was no correlation with site of metastases (P > 0.05).</p><p><b>CONCLUSION</b>Serum HER-2 level was strongly correlated with tumor loads and clinical stages, thus acting as a promising predictor of cancer recurrence in breast cancer patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood
/
Breast Neoplasms
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Biomarkers, Tumor
/
Chemistry
/
Receptor, ErbB-2
/
Liver Neoplasms
/
Lung Neoplasms
Limits:
Female
/
Humans
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2004
Type:
Article
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