Analysis of interleukin-1 receptor antagonist gene polymorphism in Chinese patients with Alzheimer's disease / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 93-96, 2004.
Article
in English
| WPRIM
| ID: wpr-254017
ABSTRACT
<p><b>OBJECTIVE</b>To identify an interaction between the interleukin-1 receptor antagonist gene polymorphism and risk of Alzheimer's disease.</p><p><b>METHODS</b>The study included 117 healthy controls, 85 patients with Alzheimer's disease in a Northeastern Chinese population of Han nationality. Genotypes were determined by a polymerase chain reaction amplification of the intron 2 fragment, harbouring a variable number of short tandem nucleotide sequences. Amplification products were separated on a 2% agarose gel.</p><p><b>RESULTS</b>The allele 2 frequency was 27% in healthy controls, and 21% in patients with Alzheimer's disease. Thus for allele 2 as well as for all other alleles, genotypes, or carriage rates, no significant differences compared with controls.</p><p><b>CONCLUSIONS</b>No association of interleukin-1 receptor antagonist gene polymorphism with Alzheimer's disease was identified in this population. It is also possible that the increased risk and disease modifying effects are caused by linkage disequilibrium with other genomic variants in other nearby genes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Introns
/
China
/
Receptors, Interleukin-1
/
Asian People
/
Alleles
/
Alzheimer Disease
/
Gene Frequency
/
Genetics
/
Genotype
Type of study:
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2004
Type:
Article
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