The measurement and significance of serum chemokine RANTES in patients with chronic hepatitis B / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship of the serum chemokine RANTES level in patients with chronic hepatitis B among different clinical severity and to explore its possible reasons.</p><p><b>METHODS</b>144 patients with chronic hepatitis B were divided into mild-moderate (46), serious (51) or severe group (47) according to the different clinical severity and 18 normal cases were taken as normal control. The serum level of chemokine RANTES was detected with an ABC-ELISA assay. Statistical analysis was performed on the software of SPSS 13.0.</p><p><b>RESULTS</b>The serum chemokine RANTES levels in patients with chronic hepatitis B (2227.06 +/- 790.80, 5878.49 +/- 3334.58, 3482.77 +/- 2315.62 ng/L in mild-moderate, serious and severe group respectively) were significantly higher than that in the normal control (329.46 +/- 152.00 ng/L). The differences between each two hepatitis groups were also statistically significant (P < 0.05) and serum chemokine RANTES level in serious group was highest among them.</p><p><b>CONCLUSION</b>Serum chemokine RANTES level in patients with chronic hepatitis B elevates significantly and it might play an important role in the pathogenesis of chronic hepatitis B.</p>