Study on T cell subsets in HIV/AIDS patients / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 284-286, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-254080
ABSTRACT
<p><b>OBJECTIVE</b>Analyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development.</p><p><b>METHODS</b>T cell subsets from 15 normal control subjects, 79 HIV/ AIDS patients were detected by FCM.</p><p><b>RESULTS</b>With diesase progression, CD4+ Naive cell counts and ratio was both decreased obviously (P < 0.001); CD4+ Tcm cell counts was significantly decreased (P < 0.001), CD4+ Tcm cell ratio was obviously higher (P = 0.002); CD4 TEM cell ratio was obviously increased( P < 0.001); CD8+ T Naive cell counts and ratio was also decreased obviously (P < 0.05); CD8+ T(CM), T(EM), T(EMRA) are not significantly different.</p><p><b>CONCLUSIONS</b>The peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Case-Control Studies
/
T-Lymphocyte Subsets
/
Acquired Immunodeficiency Syndrome
/
HIV
/
CD4 Lymphocyte Count
/
Allergy and Immunology
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2008
Type:
Article
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