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The effect of entecavir treatment on HBV-specific immunity in patient with chronic hepatitis B and its relationship to HBeAg sero-conversion / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 122-123, 2008.
Article in Chinese | WPRIM | ID: wpr-254124
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Entecavir treatment on HBV-specific immunity in patient with chronic hepatitis B and its relationship to HBeAg sero-conversion.</p><p><b>METHODS</b>Serum aminotransferase (ALT), HBV DNA and HBeAg were monitored before the after entecavir treatment. At the same time point, HBV-specific T cell proliferation was determined by [3H] T-dR incorporation assay, while HBV-specific IFN-alpha secretion was measured by ELISA.</p><p><b>RESULTS</b>The level of HBV DNA and ALT was significantly decreased after entecavir treatment. Same is the titer of HBeAg. In addition, HBeAg sero-conversion was observed in some of them, in whom the HBV-specific T cell proliferation and IFN-alpha production were significantly increased.</p><p><b>CONCLUSION</b>Entecavir treatment resulted in increased HBV-specific immunity along with the inhibition of HBV replication.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Time Factors / Virology / Blood / DNA, Viral / T-Lymphocytes / Hepatitis B virus / Treatment Outcome / Interferon-alpha / Hepatitis B, Chronic Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Time Factors / Virology / Blood / DNA, Viral / T-Lymphocytes / Hepatitis B virus / Treatment Outcome / Interferon-alpha / Hepatitis B, Chronic Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2008 Type: Article