Influence of chemotherapy on Th1/Th2 cytokine switching in stomach cancer patients

Yan LI; Jing LIANG; Wen-bo LIU; Xiao-qun XU; Yue-ran ZHAO

Influence of chemotherapy on Th1/Th2 cytokine switching in stomach cancer patients / 中华肿瘤杂志

Yan LI; Jing LIANG; Wen-bo LIU; Xiao-qun XU; Yue-ran ZHAO.

Chinese Journal of Oncology ; (12): 732-734, 2004.

Article in Chinese | WPRIM | ID: wpr-254259

ABSTRACT

ABSTRACT

OBJECTIVETo observe the influence of chemotherapy on the switching of Th1/Th2 cytokines in stomach cancer patients.METHODSTh1/Th2 cytokine genes expressed by peripheral blood mononuclear cells of stomach cancer patients before and after chemotherapy were detected by RT-PCR.RESULTSThe expression of Th2 cytokines was dominant in patients before chemotherapy, and the dominancy became less marked after chemotherapy.CONCLUSIONThe immune deviation with Th2 predominance in stomach cancer patients has a tendency to become reversed after chemotherapy.

Subject(s)

Aged; Female; Humans; Male; Middle Aged; Adenocarcinoma; Drug Therapy; Allergy and Immunology; Metabolism; Antineoplastic Combined Chemotherapy Protocols; Therapeutic Uses; Fluorouracil; Interferon-gamma; Metabolism; Interleukins; Metabolism; Leucovorin; Organoplatinum Compounds; Stomach Neoplasms; Drug Therapy; Allergy and Immunology; Metabolism; Th1 Cells; Metabolism; Th2 Cells; Metabolism

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Organoplatinum Compounds / Stomach Neoplasms / Adenocarcinoma / Antineoplastic Combined Chemotherapy Protocols / Leucovorin / Interleukins / Interferon-gamma / Th2 Cells / Th1 Cells / Therapeutic Uses Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2004 Type: Article

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