TTF-1 expression and its diagnostic application in lung carcinomas / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 615-617, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-254272
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of thyroid transcription factor 1 (TTF-1) and study its application in the diagnosis of lung carcinomas.</p><p><b>METHODS</b>Of 134 specimens from lung lobectomy, 105 were primary lung carcinomas including 76 non-small cell carcinomas (NSCLCs), 28 small cell lung cancers (SCLCs) and 1 complex carcinoma (SCLC and SCC), and 29 were metastatic carcinomas. Expression of TTF-1 was detected by immunohistochemistry. The expression level of TTF-1 was graded as, +6% to 25% of tumor cells positive, ++26% to 50%, +++51% to 75%, and ++++> 76%.</p><p><b>RESULTS</b>The positive nuclear immunoreactivity of TTF-1 was identified in 23 of 28 SCLCs (82.1%), but none in squamous cell cancer (SCC) (P < 0.001). The positive expression rate of TTF-1 in lung adenocarcinomas (ACs) was 73.8% (31/42). There was no correlation between TTF-1 expression and ACs differentiation or ACs subtypes (P > 0.05). All but one (thyroid follicular carcinoma) metastatic ACs were TTF-1-positive. Mesenchymal component and lymphoid or inflammatory cells were consistently TTF-1-negative.</p><p><b>CONCLUSION</b>A significant difference of TTF-1 expression may assist in distinguishing SCLC from SCC, lymphoma or inflammatory lesions. Owing to its restrictive expression in lung tissue, TTF-1 might be used to differentiate primary from metastatic adenocarcinoma of the lung.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Transcription Factors
/
Breast Neoplasms
/
Nuclear Proteins
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Carcinoma, Non-Small-Cell Lung
/
Diagnosis
/
Diagnosis, Differential
/
Thyroid Nuclear Factor 1
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2004
Type:
Article
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