Expression of a plant associated human cancer antigen in breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 403-405, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-254324
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of a glycoprotein of plant origin in normal, benign and malignant breast tissues.</p><p><b>METHODS</b>Expression of a plant glycoprotein was examined in 5 samples of normal breast tissues, 20 fibro-adenoma and 136 breast cancer by SABC immunohistochemical staining and the results were analyzed by SPSS statistics software.</p><p><b>RESULTS</b>No positive staining was detected in normal breast tissues (0/5). Weak staining was observed in 4 of 20 (20.0%) breast fibro-adenoma. Positive staining was demonstrated in 116 out of 136 (85.3%) breast cancer specimens. The differences were statistically significant. The expression of plant-associated human cancer antigen was related to pathological grade (P < 0.05), tissue invasiveness (P < 0.01) and recurrence (P < 0.05), but not to patients' age, tumor size and c-erbB-2 expression.</p><p><b>CONCLUSION</b>The plant glycoprotein studied may be a human cancer-associated antigen which might be a potential marker of breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Plants
/
Breast
/
Breast Neoplasms
/
Biomarkers, Tumor
/
Fibroadenoma
/
Carcinoma, Ductal, Breast
/
Carcinoma, Intraductal, Noninfiltrating
/
Adenocarcinoma, Mucinous
/
Receptor, ErbB-2
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2004
Type:
Article
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